This presentation explores the systemic fate of thyroid hormones and the enzymes responsible for their metabolism. A current understanding of the role of the liver and the adrenal gland in thyroid hormone metabolism is provided. Dr. Kelly discusses lifestyle factors such as stress, sleep deprivation, diet, surgery, injuries, high alcohol intake, and exercise and their impact on the activity of the thyroid and the metabolic fate of its hormones. Nutritional and botanical interventions is outlined.