Environmental toxicity is an increasing global problem. Toxic metals such as mercury, lead, cadmium and arsenic can have significant adverse effects on a vast array of physiological/biochemical functions, and ASD appears to entail a metal retention disorder. Dr. Quig?s presentation will address
the basic principles of metal toxicology with emphasis on the scientific basis for appropriate laboratory testing for the assessment of exposure to, and net retention of toxic metals. The clinically relevant pharmacology of the commonly used metal detoxification agents (Ca-EDTA, DMSA, D-Pen and DMPS) will be discussed including options for routes of administration, metal specificity and potential side effects. Special attention will be placed on
the importance of optimal nutritional status and gastrointestinal health to support endogenous detoxification processes.