Vaccinosis is one of the main causes of chronic disease in our animal friends. The practice of annual vaccination has created a plethera of new disease syndromes and auto-immune conditions. This lecture will first look at the historical recognition of Vaccinosis and then using the recent development of rabies vaccination in horses, investigate the development of chronic disease. The use of botanical medicines and minute doses of botanical medicines will be discussed in the treatment of the tangled web of dis-ease.