As we age, enzyme output, stomach acid production, and bile secretion all decline; microflora balance is altered; peristalsis is reduced. As a result, many patients use OTC products that may temporarily resolve digestive discomforts, but do nothing to address the underlying concerns. Physiology highlights, research, and clinical perspectives that support a protocol for restoring healthy digestion and getting patients away from conventional approaches and toward more natural and holistic interventions.