Arriving at midlife for a woman has the potential to certainly be full of "life!" With multiple care giving roles, career, financial pressures and the influence of shifting hormones and a changing physical body, these changes and more can contribute to women having trouble making changes and adhering to any given treatment plan. Being able to recognize specific obstacles and adjust strategies and tactics is key to the success of any recommendation be it a prescription, dietary and exercise modifications or targeted nutritional support. This lecture will explore tips to evaluating adherence, the causes of nonadherence and tools for improving adherence.