This presentation will provide practitioners with a clinical framework with which to evaluate and treat female infertility. We will cover pertinent history taking, physical exam, and standard and supportive laboratory testing. We will discuss the most common etiologies of infertility so that you can confidently recognize them in your practice. Following a clear diagnosis, success in treating infertility comes from defining an effective treatment plan. We will review the most clinically relevant strategies to overcome the most common causes of infertility, including irregular cycles, PCOS and anovulation, poor egg quality, semen abnormalities and more.