Childbearing is often delayed until much later in life than before the late 20th century. Today, 1 in 8 couples carry the diagnosis of infertility, and conception is even more difficult and riskier after the age of 35. This presentation will provide an overview of the best tools for evaluation and support of fertility for women over 40. We will discuss how to evaluate and improve egg quality in women as well as sperm quality in men, and will discuss additional measures that can make the difference between struggle and success.