What can we do to assist nature in healing mood disorders? Mood disorders will be differentiated so that we have an understanding of what is being treated. We will identify phenomenological descriptions related to four neurotransmitters and their influence on the nervous system. A comprehensive approach to healing depression will be presented that includes biological, mentalemotional and spiritual components. Supplements, botanicals and vitamins impacting serotonin, dopamine, GABA and norepinephrine as well as general support for the brain will be discussed. We will discover when antidepressants are needed and when antidepressants are harmful. Therapeutic strategies and mind-body-spirit approaches will be discussed.