The adrenal gland contribution to neuroendocrine blance will be detailed including an expanded review of the hypothalamic - pituitary - adrenal (HPA) axis. The interrelationships between neurotransmitters and hormones will be highlighted with special consideration to HPA axis contributions to symptom complaints associated with stress in general and specifically during menopause. Hypothalamic regulators will be highlighted along
with the additional streess coping mechanisms that may be affected due to HPA dysfunction. An overview of commonly used pharmaceutical and nutritional interventions will highlight effects on neurotransmitters levels.