The prevention and treatment of autoimmune disease requires a multi-system approach beginning with Gut Associated Lymphoid Tissue (GALT) and assessment of the role of intestinal permeability. Understand the role of intestinal permeability, altered gastrointestinal milieu and auto-antibodies in the early development of immune dysregulation. Other factors, including Vitamin D, hormone metabolites, food antigens, bacterial dysbosis and attitudinal factors.