The after effects of cytotoxic treatments can greatly impair the quality of life (QOL) of cancer survivors. Understanding the pathophysiology underlying persistent fatigue, gastrointestinal symptoms, neuropathy, "chemobrain," insomnia, etc. creates a foundation from which we can address these symptoms. Using this foundation, we will review the state of the evidence for specific natural agents proven to lessen long-term side effects
and perhaps even lessen risk of recurrence.