In this presentation, we will tackle a deeper understanding of the processes of growth and metastasis alongside how natural agents affect these pathways. Using our knowledge of molecular biology coupled with outcome data on specific natural agents, we can guide our patients to the most impactful natural interventions. We will review the evidence to date on the use of the most popular natural agents. We will also emphasize multiple roles for singular agents such that QOL is optimized while reducing risk of recurrence.