A comprehensive understanding of this complex endocrinological disorder including etiology, physiology, clinical presentations, diagnostic evaluation and risk factor assessment. An in-depth integrative management to PCOS including nutrition, exercise, nutraceuticals, botanicals, bio-identical hormones, and selected use of conventional therapies. This lecture will highlight natural therapies that increase SHBG, stimulate ovulation, lower androgens and decrease androgenic effects and that enhance insulin sensitivity.