Botanicals that Inhibit Angiogenesis, Regulate Transduction Pathways and / or Enhance Nonspecific Biological Immune Response. Carcinogenesis is a multistage process consisting of apparently three major steps initiation, promotion, and progression, and it takes many years to turn into complete malignancy. Therefore, there are ample opportunities to intervene in the development of cancer before the onset of malignancy. The usage of botanical compounds can be introduced at any stage including cellular signal transduction cascades effecting angiogenesis. Carcinogenesis is a reversible process!