Many chronic and autoimmune diseases are thought to be associated with an imbalance in the immune system between Th1 and Th2 helper cells. Botanical medicines can influence the immune system in stimulating one or the other T-cell. Understanding the dynamics of T2 polarization and the effects of the herbs on this pathway will aid in a stronger botanical formula for chronic diseases such as: allergies, Graves' diseases, RA, lupus and on and on.